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Helichrysetin

Cat. No. M16235
Helichrysetin Structure
Size Price Availability Quantity
5mg USD 370  USD370 In stock
10mg USD 560  USD560 In stock
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Quality Control & Documentation
Biological Activity

Helichrysetin

Chemical Information
CAS Number 62014-87-3
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Zhiying Wang, et al. Int J Mol Med. Helichrysetin and TNF‑α synergistically promote apoptosis by inhibiting overactivation of the NF‑κB and EGFR signaling pathways in HeLa and T98G cells

[2] Ho Yen Fong, et al. Pharmacogn Mag. Helichrysetin Induces DNA Damage that Triggers JNK-Mediated Apoptosis in Ca Ski Cells

[3] Yen Fong Ho, et al. Evid Based Complement Alternat Med. Induction of apoptosis and cell cycle blockade by helichrysetin in a549 human lung adenocarcinoma cells

[4] Ping Wang, et al. Acta Pharmacol Sin. Helichrysetin inhibits gastric cancer growth by targeting c-Myc/PDHK1 axis-mediated energy metabolism reprogramming

[5] Chia-Wei Phan, et al. Nat Prod Res. The role of chalcones: helichrysetin, xanthohumol, and flavokawin-C in promoting neurite outgrowth in PC12 Adh cells

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