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GSK3326595

Cat. No. M9420
GSK3326595 Structure
Synonym:

EPZ015938; GSK-3326595

Size Price Availability Quantity
5mg USD 40  USD40 In stock
10mg USD 70  USD70 In stock
50mg USD 240  USD240 In stock
100mg USD 428  USD428 In stock
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Quality Control
Biological Activity

GSK3326595 is a potent, selective, reversible inhibitor of protein arginine methyltransferase 5 (PRMT5) with an IC50 of 6.2 nM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 452.55
Formula C24H32N6O3
CAS Number 1616392-22-3
Purity 98.60%
Solubility DMSO ≥ 25 mg/mL
Storage at -20°C
References

[1] Yuhong Luo, et al. Hepatology. MYC-Protein Arginine Methyltransferase 5 Axis Defines the Tumorigenesis and Immune Response in Hepatocellular Carcinoma

[2] Hyungsoo Kim, et al. Sci Transl Med. PRMT5 control of cGAS/STING and NLRC5 pathways defines melanoma response to antitumor immunity

[3] Shatha AbuHammad, et al. Proc Natl Acad Sci U S A. Regulation of PRMT5-MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma

[4] Hong Lin, et al. Bioorg Med Chem Lett. Nucleoside protein arginine methyltransferase 5 (PRMT5) inhibitors

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  Catalog
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Keywords: GSK3326595, EPZ015938; GSK-3326595 supplier, PRMTs, inhibitors

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