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GSK3326595

Cat. No. M9420
GSK3326595 Structure
Synonym:

EPZ015938; GSK-3326595

Size Price Availability Quantity
50mg USD 250 In stock
100mg USD 450 In stock
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Quality Control
Biological Activity

GSK3326595 is a potent, selective, reversible inhibitor of protein arginine methyltransferase 5 (PRMT5) with an IC50 of 6.2 nM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 452.55
Formula C24H32N6O3
CAS Number 1616392-22-3
Purity 98.60%
Solubility DMSO ≥ 25 mg/mL
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: GSK3326595, EPZ015938; GSK-3326595 supplier, Histone Methyltransferase, inhibitors

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