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Goserelin

Cat. No. M1835

Goserelin Structure
Size Price Availability Quantity
10mg USD 145 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Goserelin is an injectable gonadotropin releasing hormone superagonist (GnRH agonist), also known as a luteinizing hormone releasing hormone (LHRH) agonist. Goserelin is a synthetic analogue of a naturally occurring luteinising-hormone releasing hormone (LHRH). Goserelin Acetate is a potent GnRH (LHRH) agonist. After a transient increase, continuous administration of goserelin results in downregulation of LH and FSH levels followed by a suppression of ovarian and testicular steroid biosynthesis. It rapidly binds to the LHRH receptor cells in the pituitary gland thus leading to an initial increase in production of luteinizing hormone and thus leading to an initial increase in the production of corresponding sex hormones.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 1329.46
Formula C59H84N18O14.C2H4O2
CAS Number 145781-92-6
Purity >99%
Solubility DMSO
Storage at -20°C
References

Goserelin and bicalutamide treatments alter the expression of microRNAs in the prostate.
Lehmusvaara et al. Prostate. 2012 Jun 5. PMID: 22674191.

Stimulation of a non-functioning pituitary macroadenoma after administration of goserelin acetate for locally advanced prostate cancer causing a sustained elevation in PSA and testosterone.
Youssef et al. Can Urol Assoc J. 2012 Apr;6(2):E84-6. PMID: 22511442.

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Keywords: Goserelin supplier, LHRH/GnRH, inhibitors

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