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GLP-1(7-37)

Cat. No. M11207
GLP-1(7-37) Structure
Synonym:

Insulinotropin (human);Peptide GLP-1 (human glucose-lowering peptide-1)

Size Price Availability Quantity
1mg USD 250  USD250 In stock
5mg USD 420  USD420 In stock
10mg USD 650  USD650 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Glp-1 (7-37) is an intestinal insulin hormone that enhances glucose-induced insulin secretion.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 3355.67
Formula C151H228N40O47
CAS Number 106612-94-6
Purity >99%
Solubility Water ≥ 20 mg/mL
Storage protect from light , dry , sealed
References

[1] Jinhua Zhang, et al. J Pept Sci. Efficient synthesis of Aib 8 -Arg 34 -GLP-1 (7-37) by liquid-phase fragment condensation

[2] Seyed Ebrahim Alavi, et al. Bioconjug Chem. Developing GLP-1 Conjugated Self-Assembling Nanofibers Using Copper-Catalyzed Alkyne-Azide Cycloaddition and Evaluation of Their Biological Activity

[3] No authors listed. Mol Cell Endocrinol. Liraglutide

[4] Torsten P Vahl, et al. J Clin Endocrinol Metab. Effects of GLP-1-(7-36)NH2, GLP-1-(7-37), and GLP-1- (9-36)NH2 on intravenous glucose tolerance and glucose-induced insulin secretion in healthy humans

[5] H C Fehmann, et al. Mol Cell Endocrinol. Glucagon-like peptide-1(7-37)/(7-36)amide is a new incretin

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Keywords: GLP-1(7-37), Insulinotropin (human);Peptide GLP-1 (human glucose-lowering peptide-1) supplier, Glucagon Receptor, inhibitors

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