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GDC-0575 dihydrochloride

Cat. No. M13621
GDC-0575 dihydrochloride Structure
Synonym:

ARRY-575 dihydrochloride; RG7741 dihydrochloride

Size Price Availability
5mg USD 210  USD210 4-7 Days
10mg USD 360  USD360 4-7 Days
25mg USD 720  USD720 4-7 Days
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

GDC-0575 dihydrochloride (ARRY-575 dihydrochloride) is an orally bioavailable CHK1 inhibitor, with an IC50 of 1.2 nM, and has antitumor activity.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 451.19
Formula
CAS Number 1657014-42-0
Purity >99%
Solubility DMSO 65 mg/mL
Water 25 mg/mL
Storage 2-8°C, dry, sealed
References

[1] Min Li, et al. Onco Targets Ther. GDC-0575, a CHK1 Inhibitor, Impairs the Development of Colitis and Colitis-Associated Cancer by Inhibiting CCR2 + Macrophage Infiltration in Mice

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  Catalog
Abmole Inhibitor Catalog




Keywords: GDC-0575 dihydrochloride, ARRY-575 dihydrochloride; RG7741 dihydrochloride supplier, Checkpoint, inhibitors

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