γ-Glutamyl Transferase, also known as GGT and γ-GT, is a transferase that acts as a catalyst in the transfer of γ-glutamyl functional groups from a molecule such as glutathione to an acceptor, which may be an amino acid, a peptide or water. γ-Glutamyl Transferase plays a key role in the γ-glutamyl cycle.
| CAS Number | 9046-27-9 |
| Storage | -20°C, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] Shih-Wei Lai. Osteoporos Int. Gamma-glutamyl-transferase and hip fracture
[5] J B Whitfield. Crit Rev Clin Lab Sci. Gamma glutamyl transferase
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