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G-5555

Cat. No. M13706
G-5555 Structure
Size Price Availability
5mg USD 110  USD110 4-7 Days
10mg USD 160  USD160 4-7 Days
25mg USD 360  USD360 4-7 Days
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

G-5555 is a potent p21-activated kinase 1 (PAK1) inhibitor with Kis of 3.7 nM and 11 nM for PAK1 and PAK2, respectively.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 492.96
Formula
CAS Number 1648863-90-4
Purity >99%
Solubility DMSO 25 mg/mL
Storage 2-8°C, dry, sealed
References

[1] Hai-Feng Qiao, et al. J Reprod Immunol. Retraction notice to "G-5555 synergized miR-485-5p to alleviate cisplatin resistance in ovarian cancer cells via Pi3k/Akt signaling pathway" [J. Reprod. Immunol. 140C (2020) 103129]

[2] Roberta Tesch, et al. J Med Chem. Structure-Based Design of Selective Salt-Inducible Kinase Inhibitors

[3] Hai-Feng Qiao, et al. J Reprod Immunol. G-5555 synergized miR-485-5p to alleviate cisplatin resistance in ovarian cancer cells via Pi3k/Akt signaling pathway

[4] Christina M Knippler, et al. Endocr Relat Cancer. MAPK- and AKT-activated thyroid cancers are sensitive to group I PAK inhibition

[5] Chudi O Ndubaku, et al. ACS Med Chem Lett. Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-pK a Polar Moiety

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  Catalog
Abmole Inhibitor Catalog




Keywords: G-5555 supplier, PAK, inhibitors

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