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Frangulin A

Cat. No. M16212
Frangulin A Structure
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Frangulin A

Chemical Information
CAS Number 521-62-0
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Magdalena Westermann, et al. Chem Biol Interact. Inhibition of human carbonyl reducing enzymes by plant anthrone and anthraquinone derivatives

[2] Immanuel Rosenthal, et al. J Nat Prod. Validated method for the analysis of frangulins A and B and glucofrangulins A and B using HPLC and UHPLC

[3] Sophie Godard, et al. Plant Physiol Biochem. Induction of defence mechanisms in grapevine leaves by emodin- and anthraquinone-rich plant extracts and their conferred resistance to downy mildew

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