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FKBP51F67V-selective antagonist Ligand2

Cat. No. M41342
FKBP51F67V-selective antagonist Ligand2 Structure
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FKBP51F67V-selective antagonist Ligand2 is a potent FKBP51 F67V-selective antagonist ligand.

Chemical Information
Molecular Weight 760.91
Formula C43H56N2O10
CAS Number 1680228-76-5
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Jun Cao et al. Front Oncol. Phase 1b clinical trial of pucotenlimab (HX008), a novel anti-PD-1 monoclonal antibody, combined with gemcitabine and cisplatin in the first-line treatment of metastatic triple-negative breast cancer

[2] Hongmei Zheng et al. Int J Biol Sci. New insights into the important roles of tumor cell-intrinsic PD-1

[3] Kamila Kolanska et al. Reprod Biomed Online. Absence of predictable long-term molecular effect of ulipristal acetate (UPA) on the endometrium

[4] Matthew L Stone et al. Am J Physiol Lung Cell Mol Physiol. Sphingosine-1-phosphate receptor 1 agonism attenuates lung ischemia-reperfusion injury

[5] I Hosokawa et al. J Periodontal Res. Proinflammatory effects of muramyldipeptide on human gingival fibroblasts

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Keywords: FKBP51F67V-selective antagonist Ligand2 supplier, FKBP (FK506-binding protein), inhibitors, activators

 
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