FITC-Dextran is a marker consisting of coupling fluorescein-isothiocyanate to dextran.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||Water ≥ 30 mg/mL|
|Storage||4°C, protect from light, dry, sealed|
Analysis of Lysosomal pH by Flow Cytometry Using FITC-Dextran Loaded Cells.
Eriksson I, et al. Methods Mol Biol. 2017;1594:179-189. PMID: 28456983.
Fluorescein Isothiocyanate (FITC)-Dextran Extravasation as a Measure of Blood-Brain Barrier Permeability.
Natarajan R, et al. Curr Protoc Neurosci. 2017 Apr 10;79:9.58.1-9.58.15. PMID: 28398646.
High and Low Molecular Weight Fluorescein Isothiocyanate (FITC)-Dextrans to Assess Blood-Brain Barrier Disruption: Technical Considerations.
Hoffmann A, et al. Transl Stroke Res. 2011 Mar;2011 Mar. PMID: 21423333.
|Related Fluorescent Dye Products|
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Coumarin 6 is a fluorescent dye frequently used to facilitate the traceability of drug delivery systems in vitro.
Calcein is a fluorescent dye and self-quenching probe, used as a complexometric indicator for titration of calcium ions with EDTA, and for fluorometric determination of calcium.
4,4-Difluoro-1,3,5,7,8-Pentamethyl-4-Bora-3a,4a-Diaza-s-Indacene (BODIPY 493/503) is a lipophilic fluorescent probe that localizes to polar lipids and can be used to label cellular neutral lipid contents, particularly those localized to lipid droplets, in live and fixed cells.
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