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FITC-Dextran is a marker consisting of coupling fluorescein-isothiocyanate to dextran.
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
| Molecular Weight | |
| Formula | |
| CAS Number | 60842-46-8 |
| Purity | MW. ~10000 |
| Solubility | Water ≥ 30 mg/mL |
| Storage | 4°C, protect from light, dry, sealed |
Analysis of Lysosomal pH by Flow Cytometry Using FITC-Dextran Loaded Cells.
Eriksson I, et al. Methods Mol Biol. 2017;1594:179-189. PMID: 28456983.
Fluorescein Isothiocyanate (FITC)-Dextran Extravasation as a Measure of Blood-Brain Barrier Permeability.
Natarajan R, et al. Curr Protoc Neurosci. 2017 Apr 10;79:9.58.1-9.58.15. PMID: 28398646.
High and Low Molecular Weight Fluorescein Isothiocyanate (FITC)-Dextrans to Assess Blood-Brain Barrier Disruption: Technical Considerations.
Hoffmann A, et al. Transl Stroke Res. 2011 Mar;2011 Mar. PMID: 21423333.
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