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FIPI

Cat. No. M5201
FIPI Structure
Synonym:

5-Fluoro-2-indolyl deschlorohalopemide

Size Price Availability Quantity
5mg USD 80 In stock
10mg USD 120 In stock
50mg USD 420 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

FIPI is a derivative of halopemide which potently inhibits both PLD1 (IC50 = 25 nM) and PLD2 (IC50 = 20 nM). FIPI prevents PLD regulation of F-actin cytoskeleton reorganization, cell spreading, and chemotaxis.

In vitro: FIPI was added into the Parental CHO cells culture media 1 h before performing an in vivo PLD assay and was found to be a potent inhibitor of PLD2 with an IC50 of 10 nM. PLD1 activity was inhibited even more strongly by FIPI (IC50 = 1 nM).

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 421.47
Formula C23H24FN5O2
CAS Number 939055-18-2
Purity >99%
Solubility DMSO 10 mg/mL
Storage at -20°C
References

5-Fluoro-2-indolyl des-chlorohalopemide (FIPI), a phospholipase D pharmacological inhibitor that alters cell spreading and inhibits chemotaxis.
Su W, et al. Mol Pharmacol. 2009 Mar;75(3):437-46. PMID: 19064628.

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  Catalog
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Keywords: FIPI, 5-Fluoro-2-indolyl deschlorohalopemide supplier, Phospholipase, inhibitors

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