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Avexitide (Exendin 9-39)

Cat. No. M10089
Avexitide (Exendin 9-39) Structure
Synonym:

Exendin Fragment 9-39; Exendin-3 (9-39) amide

Size Price Availability Quantity
1mg USD 216  USD240 In stock
5mg USD 639  USD710 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Avexitide (Exendin 9-39) is an antagonist of glucagon-like peptide-1 (GLP-1) receptor, and also acts as an inhibitor of glucosedependent insulinotropic polypeptide (GIP)-receptor binding. Avexitide (Exendin 9-39) is a competitive inhibitor of exendin-3 and exendin-4. It also prevents the production of cAMP by GIP. GLP-1, along with GIP, acts as a physiological incretin. Avexitide (Exendin 9-39) has been used to study its effect on basal microvascular permeability.

Amino Acid Sequence

Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 3369.76
Formula C149H234N40O47S
CAS Number 133514-43-9
Purity >99%
Solubility Water 30 mg/mL
Storage -20°C, dry, sealed
References

Glucagon-like peptide-1 protects mesenteric endothelium from injury during inflammation
Kristopher C Dozier, et al. Peptides. 2009 Sep;30(9):1735-41. PMID: 19560500.

Effects of the novel (Pro3)GIP antagonist and exendin(9-39)amide on GIP- and GLP-1-induced cyclic AMP generation, insulin secretion and postprandial insulin release in obese diabetic (ob/ob) mice: evidence that GIP is the major physiological incretin
V A Gault, et al. Diabetologia. 2003 Feb;46(2):222-30. PMID: 12627321.

Glucagon-like peptide 1 has a physiological role in the control of postprandial glucose in humans: studies with the antagonist exendin 9-39
C M Edwards, et al. Diabetes. 1999 Jan;48(1):86-93. PMID: 9892226.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Avexitide (Exendin 9-39), Exendin Fragment 9-39; Exendin-3 (9-39) amide supplier, Glucagon Receptor, inhibitors

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