Evans blue is a biological dye, for detection of cell survival. Evans Blue can not penetrate healthy cell membrane, but can penetrate into death cell. Evans Blue is also a potent inhibitor of L-glutamate uptake via the membrane bound excitatory amino acid transporter (EAAT). It is able to antagonize AMPA and kainate receptor mediated currents with IC50 values of 220 and 150 nM, respectively.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||Water 1 mg/mL|
|Storage||2-8°C, dry, protect from light, sealed|
Neuroprotective Effects of Metformin on Traumatic Brain Injury in Rats Is Associated With the AMP-activated Protein Kinase Signaling Pathway
Siavash Rahimi, et al. Metab Brain Dis. 2020 Jul 3. PMID: 32621159.
The Effect of O-1602, a GPR55 Agonist, on the Cyclophosphamide-Induced Rat Hemorrhagic Cystitis
Andrzej Wrobel, et al. Eur J Pharmacol. 2020 Jun 29;173321. PMID: 32615180.
Haem Oxygenase Protects Against Thrombocytopaenia and Malaria-Associated Lung Injury
Isaclaudia G de Azevedo-Quintanilha, et al. Malar J. 2020 Jul 1;19(1):234. PMID: 32611348.
|Related Fluorescent Dye Products|
Streptavidin is a tetrameric protein purified from Streptomyces sp. that binds very tightly to the vitamin biotin with a Kd of ~ 10-14 mol/l.
Coumarin 6 is a fluorescent dye frequently used to facilitate the traceability of drug delivery systems in vitro.
Calcein is a fluorescent dye and self-quenching probe, used as a complexometric indicator for titration of calcium ions with EDTA, and for fluorometric determination of calcium.
4,4-Difluoro-1,3,5,7,8-Pentamethyl-4-Bora-3a,4a-Diaza-s-Indacene (BODIPY 493/503) is a lipophilic fluorescent probe that localizes to polar lipids and can be used to label cellular neutral lipid contents, particularly those localized to lipid droplets, in live and fixed cells.
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