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EUK 134

Cat. No. M2695

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EUK 134 Structure
Size Price Availability Quantity
10mM*1mL in DMSO USD 40  USD40 In stock
10mg USD 30  USD30 In stock
25mg USD 60  USD60 In stock
50mg USD 90  USD90 In stock
100mg USD 135  USD135 In stock
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Quality Control & Documentation
Biological Activity

EUK 134, a synthetic superoxide dismutase (SOD)/catalase mimetic, exhibits potent antioxidant activities, and inhibits the formation of β-amyloid and related amyloid fibril.

Customer Product Validations & Biological Datas
Source Front Mol Neurosci (2017). Figure 3. EUK-134
Method Determination of Mitochondrial Superoxide Generation
Cell Lines Neurons
Concentrations 20 μM
Incubation Time 2 h
Results In agreement with these findings, cultures pre-incubated for 2 h with the mito-protector agent EUK-134 (20 μM) exhibited a significant decrease in neuronal superoxide levels following AbOs addition, as observed in the pseudo color images shown in Figure 3D.
Chemical Information
Molecular Weight 416.74
Formula C18H18ClMnN2O4
CAS Number 81065-76-1
Solubility (25°C) DMSO 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Thi Thanh Huong Pham, et al. Effects of electrotactic exercise and antioxidant EUK-134 on oxidative stress relief in Caenorhabditis elegans

[2] Koichi Himori, et al. Superoxide dismutase/catalase mimetic EUK-134 prevents diaphragm muscle weakness in monocrotalin-induced pulmonary hypertension

[3] Sheldon Magder, et al. Preservation of renal blood flow by the antioxidant EUK-134 in LPS-treated pigs

[4] John M Lawler, et al. EUK-134 ameliorates nNOSμ translocation and skeletal muscle fiber atrophy during short-term mechanical unloading

[5] Prabal K Chatterjee, et al. EUK-134 reduces renal dysfunction and injury caused by oxidative and nitrosative stress of the kidney

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Keywords: EUK 134 supplier, Amyloid, inhibitors, activators

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