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Ergosterol peroxide

Cat. No. M17620
Ergosterol peroxide Structure
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Biological Activity

Ergosterol peroxide

Chemical Information
CAS Number 2061-64-5
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Yong-Un Jeong, et al. Int J Mol Sci. Ergosterol Peroxide from the Medicinal Mushroom Ganoderma lucidum Inhibits Differentiation and Lipid Accumulation of 3T3-L1 Adipocytes

[2] Thuluz Meza-Menchaca, et al. Biomolecules. Insights into Ergosterol Peroxide's Trypanocidal Activity

[3] Beixian Zhou, et al. Eur J Pharmacol. Ergosterol peroxide suppresses influenza A virus-induced pro-inflammatory response and apoptosis by blocking RIG-I signaling

[4] Taotao Ling, et al. Org Biomol Chem. Development of ergosterol peroxide probes for cellular localisation studies

[5] Simon Merdivan, et al. Int J Med Mushrooms. Ergosterol Peroxide: A Mushroom-Derived Compound with Promising Biological Activities-A Review

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