EIPA is a tRPP3 channel inhibitor (IC50 = 10.5 μM). EIPA inhibits the Na+/H+ exchanger (NHE). Derivative of amiloride.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||1eq. HCl 14.99 mg/mL|
A novel class of positive allosteric modulators of metabotropic glutamate receptor subtype 1 interact with a site distinct from that of negative allosteric modulators.
Hemstapat, et al. Mol Pharmacol. 2006;70: 616. PMID: 16645124.
|Related TRP Channel Products|
AC1903 is a specific inhibitor of TRPC5 channel.
MK6-83 is an agonist of the transient receptor potential channel ML3 (TRPML3).
Nonivamide (also called pelargonic acid vanillylamide or PAVA) can activate the TRPV1 receptor, thus, stimulate the firing rate of dopaminergic neurons in the ventral tegmental area of the brain and to increase the expression of the serotonin receptor gene HTR2A.
HC-067047 is a potent, selective inhibitor of hTRPV4.
Capsazepine is a specific vanilloid receptor antagonist; synthetic analog of capsaicin.
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