EIPA is a tRPP3 channel inhibitor (IC50 = 10.5 μM). EIPA inhibits the Na+/H+ exchanger (NHE). Derivative of amiloride.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||1eq. HCl 14.99 mg/mL|
A novel class of positive allosteric modulators of metabotropic glutamate receptor subtype 1 interact with a site distinct from that of negative allosteric modulators.
Hemstapat, et al. Mol Pharmacol. 2006;70: 616. PMID: 16645124.
|Related TRP Channel Products|
HC-067047 is a potent, selective inhibitor of hTRPV4.
ML SA1 is a activator of TRPML channels.
BCTC is a tRPV1 antagonist.
Camphor is a waxy, flammable, white or transparent solid with a strong aroma, often used to relieve pain, reduce itching and treat fungal infections. It can activate TRPV1 and TRPV3.
Diphenyleneiodonium chloride (DPI) is an irreversible inhibitor of iNOS and eNOS with IC50 values of 50 nM and 0.3 µM, respectively.
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