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EIPA

Cat. No. M6705
EIPA Structure
Synonym:

L593754; MH 12-43; Ethylisopropylamiloride

Size Price Availability Quantity
10mg USD 150 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

EIPA is a tRPP3 channel inhibitor (IC50 = 10.5 μM). EIPA inhibits the Na+/H+ exchanger (NHE). Derivative of amiloride.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 299.76
Formula C11H18ClN7O
CAS Number 1154-25-2
Purity >98%
Solubility 1eq. HCl 14.99 mg/mL
Storage at -20°C
References

A novel class of positive allosteric modulators of metabotropic glutamate receptor subtype 1 interact with a site distinct from that of negative allosteric modulators.
Hemstapat, et al. Mol Pharmacol. 2006;70: 616. PMID: 16645124.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: EIPA, L593754; MH 12-43; Ethylisopropylamiloride supplier, TRP Channel, inhibitors

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