|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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|Pronase E (Activity ≥ 7000 U/g)
Pronase E (Activity ≥ 7000 U/g) is a proteolytic enzyme mixture obtained from Streptomyces griseus that is able to digest proteins into individual amino acids.
D-(+)-Malic acid (D-Malic acid) is an active isomer of Malic acid and acted as a competitive inhibitor of L(-)malic acid transport.
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