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EC5026 (BPN-19186)

Cat. No. M10464
EC5026 (BPN-19186) Structure
Synonym:

BPN-19186

Size Price Availability Quantity
10mg USD 126  USD140 In stock
50mg USD 378  USD420 In stock
100mg USD 630  USD700 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

EC5026 (BPN-19186) is a first-in-class, potent and orally active soluble inhibitor of Epoxide Hydrolase (sEH). EC5026 has the potential to relieve pain by stabilizing natural analgesic and anti-inflammatory mediators. In vivo, EC5026 (BPN-19186) has already shown efficacy for treating pain with no apparent adverse or addictive effects in laboratory animals and relieving naturally occurring pain in dogs, cats and horses.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 405.39
Formula C18H23F4N3O3
CAS Number 1809885-32-2
Purity >98%
Solubility DMSO ≥ 100 mg/mL
Storage at -20°C
References

From the Design to the In Vivo Evaluation of Benzohomoadamantane-Derived Soluble Epoxide Hydrolase Inhibitors for the Treatment of Acute Pancreatitis
Sandra Codony, et al. J Med Chem. 2021 May 13;64(9):5429-5446. PMID: 33945278.

Movement to the Clinic of Soluble Epoxide Hydrolase Inhibitor EC5026 as an Analgesic for Neuropathic Pain and for Use as a Nonaddictive Opioid Alternative
Bruce D Hammock, et al. J Med Chem. 2021 Feb 25;64(4):1856-1872. PMID: 33550801.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: EC5026 (BPN-19186), BPN-19186 supplier, inhibitors

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