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Dyclonine HCl

Cat. No. M5603
Dyclonine HCl Structure
Size Price Availability Quantity
50mg USD 65 In stock
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Quality Control
Biological Activity

Dyclonine HCl is a hydrochloride salt form of dyclonine which is an oral anaesthetic, reversibly binds to activated sodium channels on the neuronal membrane, thereby decreasing the neuronal membrane's permeability to sodium ions, leading to an increased threshold for excitation.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 325.87
Formula C18H27NO2.HCl
CAS Number 536-43-6
Purity
Solubility 36 mg/mL in Ethanol
Storage at -20°C
References

Dyclonine rescues frataxin deficiency in animal models and buccal cells of patients with Friedreich's ataxia.
Sahdeo S, et al. Hum Mol Genet. 2014 Dec 20;23(25):6848-62. PMID: 25113747.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Dyclonine HCl supplier, Sodium Channel, inhibitors

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