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DNJ

Cat. No. M19463
DNJ Structure
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Quality Control
  • Current batch:
  • Purity >95%
  • COA
  • MSDS
Biological Activity

DNJ

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight
Formula C18H21NO5
CAS Number 73285-50-4
Purity >95%
Solubility
Storage at -20°C
References

[1] Soo Takasu, et al. Food Funct. Evaluation and development of a novel pre-treatment method for mulberry leaves to enhance their bioactivity via enzymatic degradation of GAL-DNJ to DNJ

[2] Lukas Schmauder, et al. Sci Rep. Nematode CDC-37 and DNJ-13 form complexes and can interact with HSP-90

[3] Lucia Marchetti, et al. Plants (Basel). Determination of 1-Deoxynojirimycin (1-DNJ) in Leaves of Italian or Italy-Adapted Cultivars of Mulberry ( Morus sp.pl.) by HPLC-MS

[4] Tian-Tian Lu, et al. Eur J Med Chem. Synthesis and glycosidase inhibition of 5-C-alkyl-DNJ and 5-C-alkyl-l-ido-DNJ derivatives

[5] Haijun Wang, et al. Curr Med Chem. 1-Deoxynojirimycin and its Derivatives: A Mini Review of the Literature

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