Diphenyleneiodonium chloride (DPI) is an irreversible inhibitor of iNOS and eNOS with IC50 values of 50 nM and 0.3 µM, respectively. DPI chloride has been used to inhibit other flavoenzymes such as neutrophil NADPH oxidase and to bind strongly to flavoproteins. DPI chloride is thus a powerful and specific inhibitor of several important enzymes, including NADPH cytochrome P450 oxidoreductase, NADPH oxidases and NADPH-ubiquinone oxidoreductase.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||DMSO 6 mg/mL (with warming)|
Identification of a novel small-molecule agonist for human G protein-coupled receptor 3.
Ye C, et al. J Pharmacol Exp Ther. 2014 Jun;349(3):437-43. PMID: 24633425.
Inhibition of cytochrome P450 reductase by the diphenyliodonium cation. Kinetic analysis and covalent modifications.
Tew DG. Biochemistry. 1993 Sep 28;32(38):10209-15. PMID: 8399148.
Inhibitory actions of diphenyleneiodonium on endothelium-dependent vasodilatations in vitro and in vivo.
Wang YX, et al. Br J Pharmacol. 1993 Nov;110(3):1232-8. PMID: 7507779.
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