DiO is used to label muscle membranes, and the membranes accessible to the dye were observed by confocal laser scanning microscopy. 3,3′-Dioctadecyloxacarbocyanine perchlorate is a cationic oxacarbocyanine dye. The absorption and fluorescence spectra of 3,3'-dioctadecyloxacarbocyanine, a cationic oxacarbocyanine dye have been studied in aqueous and nonaqueous media containing egg phosphatidylcholine (PC) as well as in different solvents of diverse nature. The maximum excitation wavelength is 484nm, and the maximum emission wavelength is 501nm.
ACS Nano. 2023 Sep 12;17(17):16770-16786.
Sequential Targeting Hybrid Nanovesicles Composed of Chimeric Antigen Receptor T-Cell-Derived Exosomes and Liposomes for Enhanced Cancer Immunochemotherapy
DiO perchlorate purchased from AbMole
Front Bioeng Biotechnol. 2023 Feb 21;11:1098172.
Extracellular vesicles secreted by human gingival mesenchymal stem cells promote bone regeneration in rat femoral bone defects
DiO perchlorate purchased from AbMole
| Molecular Weight | 881.72 |
| Formula | C53H85ClN2O6 |
| CAS Number | 34215-57-1 |
| Solubility (25°C) | DMF 5 mg/mL Soluble in DMSO Soluble in Ethanol |
| Storage | 4°C, protect from light, dry, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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FM1-43 is a very lipophilic, water-soluble styrene dyes, can specifically bind to cell membranes and inner membrane organelles to produce fluorescence. FM1-43 is widely used in endocytic and exospic membrane structure markers. |
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