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Digoxin

Cat. No. M3935
Digoxin Structure
Synonym:

12β-Hydroxydigitoxin

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50mg USD 70  USD70 Out of stock
100mg USD 100  USD100 Out of stock
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Quality Control & Documentation
Biological Activity

Digoxin is a potent inhibitor of Na+/K+-ATPase, has the potential for arrhythmia and heart failure.

Customer Product Validations & Biological Datas
Source Nature (2011). Figure 4. Digoxin
Method Flow cytometry
Cell Lines Th17 cells
Concentrations 10 μM
Incubation Time 6 d
Results In vitro digoxin treatment of expanded mouse Th17 cells derived from immunized mice inhibited both IL-23R (Fig. 4a) and IL-17a expression without affecting IFN-γ expression (Fig. 4b).
Source Nature (2011). Figure 1. Digoxin
Method luciferase reporter
Cell Lines Drosophila S2 cell
Concentrations 10 μM
Incubation Time
Results Inhibition of RORγ activity by digoxin was specific, as there was no effect on the transcriptional activity of VP16 or of the related nuclear hormone receptors RORα and DHR3
Protocol (for reference only)
Cell Experiment
Cell lines A549 cells
Preparation method Cells were treated with various concentrations of digoxin for 24 h and seeded in transwell chambers (8-μm pore size, 6.5-mm diameter), which were or were not coated with Matrigel. The upper wells were filled with serum-free media and A549 cells (2×104 or 1×104 cells per well). The lower wells of the transwells contained the same media with 10% FBS and digoxin at various concentrations.
Concentrations 250 nM
Incubation time 24 h
Animal Experiment
Animal models Sprague Dawley Rats
Formulation 0.5% sodium carboxymethylcellulose
Dosages 25.6 μmol/kg
Administration oral gavage
Chemical Information
Molecular Weight 780.94
Formula C41H64O14
CAS Number 20830-75-5
Solubility (25°C) DMSO 40 mg/mL
Storage -20°C, protect from light, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Okin PM, et al. J Hypertens. Digoxin use and risk of mortality in hypertensive patients with atrial fibrillation.

[2] Washam JB, et al. Lancet. Digoxin use in patients with atrial fibrillation and adverse cardiovascular outcomes: a retrospective analysis of the Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF).

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Keywords: Digoxin, 12β-Hydroxydigitoxin supplier, Sodium Channel, inhibitors, activators


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