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Digitonin

Cat. No. M5020
Digitonin Structure
Synonym:

NSC-23471

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100mg USD 90 4-7 Days
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Quality Control
  • Current batch:
  • Purity 50%
  • COA
  • MSDS
Biological Activity

Digitonin is a glycoside obtained from Digitalis purpurea, which could increase cell permeability by binding to cholesterol molecules and reduce tumor growth.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 1229.31
Formula C56H92O29
CAS Number 11024-24-1
Purity 50%
Solubility DMSO 10 mM
Storage at -20°C
References

Digitonin enhances the efficacy of carboplatin in liver tumour after intra-arterial administration.
Lindner PG, et al. Cancer Chemother Pharmacol. 1997;40(5):444-8. PMID: 9272123.

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  Catalog
Abmole Inhibitor Catalog 2017




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