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DiBAC4(3)

Cat. No. M13779
DiBAC4(3) Structure
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25mg USD 300  USD300 In stock
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Biological Activity

DiBAC4(3) is a voltage-sensitive fluorescent dye (λex=490 nm, λem=505 nm).

Chemical Information
Molecular Weight 516.63
CAS Number 70363-83-6
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage 2-8°C, protect from light
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Cristina Bosch Calero, et al. Channels (Austin). The smooth muscle-type β1 subunit potentiates activation by DiBAC4(3) in recombinant BK channels

[2] Fabiana S Scornik, et al. Am J Physiol Heart Circ Physiol. DiBAC₄(3) hits a "sweet spot" for the activation of arterial large-conductance Ca²⁺-activated potassium channels independently of the β₁-subunit

[3] Nstor J Oviedo, et al. CSH Protoc. Live Imaging of Planarian Membrane Potential Using DiBAC4(3)

[4] A Yamada, et al. Jpn J Pharmacol. Usefulness and limitation of DiBAC4(3), a voltage-sensitive fluorescent dye, for the measurement of membrane potentials regulated by recombinant large conductance Ca2+-activated K+ channels in HEK293 cells

[5] D E Epps, et al. Chem Phys Lipids. Characterization of the steady-state and dynamic fluorescence properties of the potential-sensitive dye bis-(1,3-dibutylbarbituric acid)trimethine oxonol (Dibac4(3)) in model systems and cells

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