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Deslorelin Acetate

Cat. No. M1836
Deslorelin Acetate  Structure
Synonym:

H 4065

Size Price Availability Quantity
5mg USD 90  USD90 In stock
10mg USD 145  USD145 In stock
50mg USD 420  USD420 In stock
100mg USD 630  USD630 In stock
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Quality Control & Documentation
Biological Activity

Deslorelin is an injectable gonadotropin releasing hormone super-agonist (GnRH agonist) also known as an LHRH agonist. It stops the production of sex hormones (testosterone and oestrogen). Unlike other GnRH agonists, which are mainly used to inhibit luteinizing hormone and follicle-stimulating hormone by their ultimate downregulation of the pituitary gland, Deslorelin is primarily used for the initial flare effect upon the pituitary, and its associated surge of LH secretion. After a transient increase, continuous administration of deslorelin results in downregulation of LH and FSH levels followed by a suppression of ovarian and testicular steroid biosynthesis.

Chemical Information
Molecular Weight 1342.5
Formula C64H83N17O12.C2H4O2
CAS Number 57773-65-6
Solubility (25°C) DMSO 10 mM
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Cetin et al. Reprod Domest Anim. Long-Term Effect of Deslorelin Implant on Ovarian Pre-Antral Follicles and Uterine Histology in Female Rats.

[2] Novotny et al. Theriogenology. Reversible suppression of sexual activity in tomcats with deslorelin implant.

[3] Ackermann et al. Theriogenology. Ovarian activity reversibility after the use of deslorelin acetate as a short-term contraceptive in domestic queens.

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Keywords: Deslorelin Acetate , H 4065 supplier, LHRH/GnRH, inhibitors, activators


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