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Deslorelin Acetate

Cat. No. M1836
Deslorelin Acetate  Structure
Size Price Availability Quantity
10mg USD 150 In stock
50mg USD 450 In stock
200mg USD 680 In stock
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Biological Activity

Deslorelin is an injectable gonadotropin releasing hormone super-agonist (GnRH agonist) also known as an LHRH agonist. It stops the production of sex hormones (testosterone and oestrogen). Unlike other GnRH agonists, which are mainly used to inhibit luteinizing hormone and follicle-stimulating hormone by their ultimate downregulation of the pituitary gland, Deslorelin is primarily used for the initial flare effect upon the pituitary, and its associated surge of LH secretion. After a transient increase, continuous administration of deslorelin results in downregulation of LH and FSH levels followed by a suppression of ovarian and testicular steroid biosynthesis.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 1342.5
Formula C64H83N17O12.C2H4O2
CAS Number 57773-65-6
Purity 100.00%
Solubility DMSO
Storage at -20°C
References

Long-Term Effect of Deslorelin Implant on Ovarian Pre-Antral Follicles and Uterine Histology in Female Rats.
Cetin et al. Reprod Domest Anim. 2012 Jun 9. PMID: 22681444.

Reversible suppression of sexual activity in tomcats with deslorelin implant.
Novotny et al. Theriogenology. 2012 Sep 1;78(4):848-57. PMID: 22578617.

Ovarian activity reversibility after the use of deslorelin acetate as a short-term contraceptive in domestic queens.
Ackermann et al. Theriogenology. 2012 Sep 1;78(4):817-22. PMID: 22578612.

Related LHRH/GnRH Products
Goserelin

Goserelin is an injectable gonadotropin releasing hormone superagonist (GnRH agonist), also known as a luteinizing hormone releasing hormone (LHRH) agonist.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Deslorelin Acetate supplier, LHRH/GnRH, inhibitors

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