D-Ribose 5-phosphate disodium is an intermediate of the oxidative branch of the pentose phosphate pathway (PPP) and an end product of the nonoxidative branch of the PPP. D-Ribose 5-phosphate disodium is used in the synthesis of nucleotides and nucleic acids.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
|Solubility||Water 50 mg/mL|
|Storage||-20°C, dry, sealed|
Ribose-5-phosphate biosynthesis in Methanocaldococcus jannaschii occurs in the absence of a pentose-phosphate pathway
Laura L Grochowski, et al. J Bacteriol. 2005 Nov;187(21):7382-9. PMID: 16237021.
Bombesin is a tetradecapeptide, which plays an important role in the release of gastrin and the activation of G-protein receptors.
Acevaltrate inhibits the Na+/K+-ATPase activity in the rat kidney and brain hemispheres with IC50s of 22.8 μM and 42.3 μM, respectively.
Valepotriate has anti-epileptic and anti-cancer activities, it isolated from Valeriana jatamansi Jones.
TNP-470 (AGM-1470; NSC 642492) is a synthetic analog of fumagillin (or Fumagillol) and a methionine aminopeptidase-2 inhibitor.
17 alpha-Estradiol is a 5α-reductase inhibitor, and it inhibits testosterone metabolism catalyzed by 5 alpha-reductase.
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