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D-Luciferin

Cat. No. M9053
D-Luciferin Structure
Synonym:

Firefly luciferin

Size Price Availability Quantity
10mg USD 58 In stock
20mg USD 100 In stock
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Quality Control
Biological Activity

D-Luciferin is a light-emitting compound, also a natural substrate of luciferases. D-luciferin is the natural substrate of the enzyme luciferase (Luc), that catalyzes the production of the typical yellowgreen light of fireflies. The total signal intensity is plotted against the time after D-luciferin injection to generate a time-intensity curve. In addition to the peak signal, the signals at fixed time points (5, 10, 15, and 20 min) after D-luciferin injection are determined as alternatives to the peak signal.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 280.32
Formula C11H8N2O3S2
CAS Number 2591-17-5
Purity 99.89%
Solubility DMSO: ≥ 10 mg/mL (Need warming and ultrasonic)
Storage at -20°C
References

Hydrazide d-luciferin for in vitro selective detection and intratumoral imaging of Cu(2.).
Zheng Z, et al. Biosens Bioelectron. 2016 Sep 15;83:200-4. PMID: 27131992.

Aminoluciferins extend firefly luciferase bioluminescence into the near-infrared and can be preferred substrates over D-luciferin.
Mofford DM, et al. J Am Chem Soc. 2014 Sep 24;136(38):13277-82. PMID: 25208457.

Timing of imaging after d-luciferin injection affects the longitudinal assessment of tumor growth using in vivo bioluminescence imaging.
Inoue Y, et al. Int J Biomed Imaging. 2010;2010:471408. PMID: 20671955.

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Keywords: D-Luciferin, Firefly luciferin supplier, Fluorescent Dye, inhibitors

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