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Cynatratoside A

Cat. No. M17626
Cynatratoside A Structure
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Biological Activity

Cynatratoside A

Chemical Information
CAS Number 97399-96-7
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Yaqian Zhang, et al. J Ethnopharmacol. A review of the ethnopharmacology, phytochemistry and pharmacology of Cynanchumatratum

[2] Jian Yang, et al. Molecules. A C 21-Steroidal Glycoside from Cynanchum atratum Attenuates Concanavalin A-Induced Liver Injury in Mice

[3] Wen Ji-Hong, et al. Parasitology. Activity of two extracts of Cynanchum paniculatum against Ichthyophthirius multifiliis theronts and tomonts

[4] Huan Chen, et al. Steroids. Steroidal glycosides from the roots of Cynanchum amplexicaule Sieb. et Zucc

[5] Z X Zhang, et al. Chem Pharm Bull (Tokyo). Studies on the constituents of asclepiadaceae plants. LVIII. The structures of five glycosides, cynatratoside-A, -B, -C, -D, and -E, from the Chinese drug "pai-wei," Cynanchum atratum Bunge

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