Cyanine5.5 amine is a Cy5.5 analog that is also a near-infrared (NIR) fluorescent dye (Ex=648 nm, Em=710 nm) and has the advantage of a low fluorescent background. It can be used to prepare Cy5.5-labeled nanoparticles for tracking and imaging using confocal microscopy.
| Molecular Weight | 753.88 |
| Formula | C46H58Cl2N4O |
| CAS Number | 2097714-45-7 |
| Form | Solid |
| Solubility (25°C) | DMSO >100 mg/mL |
| Storage | -20°C, protect from light |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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