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Cuniloside B

Cat. No. M17032
Cuniloside B Structure
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Biological Activity

Cuniloside B

Chemical Information
CAS Number 1187303-40-7
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Allison M Heskes, et al. PLoS One. Localization of oleuropeyl glucose esters and a flavanone to secretory cavities of Myrtaceae

[2] Jasmeen Sidana, et al. Pharm Biol. Terpenoidal constituents of Eucalyptus loxophleba ssp. lissophloia

[3] Zalihe Hakki, et al. Carbohydr Res. Synthesis of the monoterpenoid esters cypellocarpin C and cuniloside B and evidence for their widespread occurrence in Eucalyptus

[4] Jason Q D Goodger, et al. Phytochemistry. Non-volatile components of the essential oil secretory cavities of Eucalyptus leaves: discovery of two glucose monoterpene esters, cuniloside B and froggattiside A

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