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Cortistatin A

Cat. No. M40507
Cortistatin A Structure
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Biological Activity

Cortistatin A is a potent, selective inhibitor of CDK8 and CDK19.

Chemical Information
Molecular Weight 472.62
Formula C30H36N2O3
CAS Number 882976-95-6
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Chuan Li et al. J Infect Dis. The Block-and-Lock Strategy for Human Immunodeficiency Virus Cure: Lessons Learned from Didehydro-Cortistatin A

[2] Juan Liang et al. Cardiovasc Diagn Ther. Cortistatin, a novel cardiovascular protective peptide

[3] Alejandro Ibáñez-Costa et al. Growth Horm IGF Res. Cortistatin: A new link between the growth hormone/prolactin axis, stress, and metabolism

[4] Guillaume Mousseau et al. Expert Rev Anti Infect Ther. Didehydro-Cortistatin A: a new player in HIV-therapy?

[5] A D Spier et al. Brain Res Brain Res Rev. Cortistatin: a member of the somatostatin neuropeptide family with distinct physiological functions

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  Catalog
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Keywords: Cortistatin A supplier, CDK, inhibitors, activators


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