Concanavalin A is a protein containing only β-sheets in its structure, and belongs to the legume lectins family. Concanavalin A stimulates acute hepatic inflammation. Concanavalin A has inhibitory effect on hepatocellular carcinoma by inducing autophagy. It can be used to construct dry eye models, as well as autoimmune hepatitis models.
Cell Mol Life Sci. 2024 Jan 12;81(1):32.
Splenectomy ameliorates liver cirrhosis by restoring the gut microbiota balance
Concanavalin A purchased from AbMole
| CAS Number | 11028-71-0 |
| Solubility (25°C) | Water 5 mg/mL PBS 5 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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