Hexapeptide-9 is an anti-aging peptide that can visibly reduce the length and depth of wrinkles.Hexapeptide-9 can reduce the strength of muscle contraction, relax muscles, reduce the occurrence of dynamic lines and eliminate fine lines;effectively reorganize collagen elasticity, increase the activity of elastin, relax facial lines, smooth wrinkles and improve relaxation. In vitro studies show that Hexapeptide-9 enhances epidermal regeneration, collagen type I and III synthesis as well as the synthesis of other important skin proteins, the regeneration of dermal-epidermal junction and the skin differentiation.
| Molecular Weight | 582.61 |
| Formula | C24H38N8O9 |
| CAS Number | 1228371-11-6 |
| Storage | 2-8°C, dry, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] F SPEIER, et al. Zentralbl Chir. [Clinical use of collafil]
[2] A E FISCHER, et al. Zentralbl Chir. [Resorption of the suture material collafil]
[3] H TELLER. Hautarzt. [Interstitial hemangioma irradiation with radioactive P32 collafil fibers]
[4] D DEZZANI. Arch Ortop. [Osteosynthesis with collafil]
[5] D SABAINO, et al. Minerva Ortop. [Osteosynthesis with collafil; experimental research]
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