All AbMole products are for research use only, cannot be used for human consumption.
CID755673 suppressed half of the PKD1 enzyme activity at 182 nm and exhibited selective PKD1 inhibition when compared with AKT, polo-like kinase 1 (PLK1), CDK activating kinase (CAK), CAMKIIalpha, and three different PKC isoforms.In cell-based assays, CID755673 blocked phorbol ester-induced endogenous PKD1 activation in LNCaP cells in a concentration-dependent manner. Functionally, CID755673 inhibited the known biological actions of PKD1 including phorbol ester-induced class IIa histone deacetylase 5 nuclear exclusion, vesicular stomatitis virus glycoprotein transport from the Golgi to the plasma membrane, and the ilimaquinone-induced Golgi fragmentation. Moreover, CID755673 inhibited prostate cancer cell proliferation, cell migration, and invasion. Treatment with CK59 and CID755673 indeed resulted in a significant dose-dependent reduction of NK cell degranulation markers and cytokine release in freshly isolated Peripheral blood mononuclear cell populations from healthy blood donors.
| Cell Experiment | |
|---|---|
| Cell lines | LNCaP or PC3 cells |
| Preparation method | Counting the number of viable cells upon trypan blue staining to determine cell proliferation . Using cellTiter-Glo Luminescent Cell Viability Assay to measure Cell proliferation by according to the manufacturer's instructions. |
| Concentrations | ~25 μM |
| Incubation time | 6 days |
| Animal Experiment | |
|---|---|
| Animal models | Rat pancreatitis model |
| Formulation | DMSO |
| Dosages | ~15 mg/kg |
| Administration | i.p. |
| Molecular Weight | 217.22 |
| Formula | C12H11NO3 |
| CAS Number | 521937-07-5 |
| Solubility (25°C) | DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related PKD Products |
|---|
| VX-407
VX-407 is a first-in-class small molecule corrector that targets the underlying cause of ADPKD in a subset with responsive PKD1 mutations. |
| BPKDi
BPKDi is a potent bipyridyl PKD inhibitor with IC50s of 1 nM, 9 nM and 1 nM for PKD1, PKD2 and PKD3, respectively. BPKDi blocks signal-dependent phosphorylation and nuclear export of class IIa HDACs in cardiomyocytes. |
| CRT0066101 dihydrochloride
CRT 0066101 is a potent protein kinase D (PKD) inhibitor. |
| CID-2011756
CID-2011756 is a cell-active ATP competitive and specific PKD1 inhibitor that inhibits phorbol ester-induced endogenous PKD1 activation in LNCaP prostate cancer cells. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.
