Free shipping on all orders over $ 500

Calcifediol

Cat. No. M2046
Calcifediol Structure
Synonym:

Calcidiol

Size Price Availability Quantity
5mg USD 115 In stock
10mg USD 195 In stock
50mg USD 780 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
Biological Activity

Calcifediol, also known as calcidiol, 25-hydroxycholecalciferol, or 25-hydroxyvitamin D (abbreviated 25(OH)D), is a major circulating metabolite of vitamin D3 and acts as a competitive inhibitor with an apparent Ki of 3.9 μM. Calcifediol suppresses PTH synthesis and secretion in bovine parathyroid cells with ED50 of 2 nM. Calcifediol is then converted in the kidneys (by the enzyme 25(OH)D-1α-hydroxylase) into calcitriol (1,25-(OH)2D3), a secosteroid hormone that is the active form of vitamin D. It can also be converted into 24-hydroxycalcidiol in the kidneys via 24-hydroxylation. In the pooled analysis, higher circulating 25(OH)D(3) concentrations were statistically significantly associated with decreased colorectal adenoma risk (highest vs. lowest quartile odds ratio = 0.59, 95% confidence interval: 0.41, 0.84).

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 400.64
Formula C27H44O2
CAS Number 19356-17-3
Purity 100.00%
Solubility DMSO 72 mg/mL
Ethanol 20 mg/mL
Storage at -20°C
References

Blood 25-hydroxyvitamin D3 concentrations and incident sporadic colorectal adenoma risk: a pooled case-control study.
Fedirko V, et al. Am J Epidemiol. 2010 Sep 1;172(5):489-500. PMID: 20650953.

Megalin-mediated endocytosis of vitamin D binding protein correlates with 25-hydroxycholecalciferol actions in human mammary cells.
Rowling MJ, et al. J Nutr. 2006 Nov;136(11):2754-9. PMID: 17056796.

Related Vitamin Products
Vitamin E succinate

Vitamin E succinate is a derivative of Vitamin E, VES can block tumor cell cycle in G1 phase, promote tumor cell differentiation and inhibit tumor Cell DNA synthesis, increase the secretion and activation of transfer growth factor β (TGF-β).

Hydroxocobalamin acetate

Hydroxocobalamin acetate (Vitamin B12a acetate) is an injectable naturally occurring form of vitamin B12.

Eldecalcitol

Eldecalcitol is an analog of 1,25-dihydroxyvitamin D3 that improves bone mineral density.

Thiamine chloride

Thiamine chloride —the biologically active form of vitamin B1—is vital for all cellular life because it is a co-factor for several essential enzymes.

Folic acid

Folic acid, a B vitamin, plays an important role in cell division and in the synthesis of amino acids and nucleic acids like DNA.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Calcifediol, Calcidiol supplier, Vitamin, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.