Calcifediol, also known as calcidiol, 25-hydroxycholecalciferol, or 25-hydroxyvitamin D (abbreviated 25(OH)D), is a major circulating metabolite of vitamin D3 and acts as a competitive inhibitor with an apparent Ki of 3.9 μM. Calcifediol suppresses PTH synthesis and secretion in bovine parathyroid cells with ED50 of 2 nM. Calcifediol is then converted in the kidneys (by the enzyme 25(OH)D-1α-hydroxylase) into calcitriol (1,25-(OH)2D3), a secosteroid hormone that is the active form of vitamin D. It can also be converted into 24-hydroxycalcidiol in the kidneys via 24-hydroxylation. In the pooled analysis, higher circulating 25(OH)D(3) concentrations were statistically significantly associated with decreased colorectal adenoma risk (highest vs. lowest quartile odds ratio = 0.59, 95% confidence interval: 0.41, 0.84).
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||DMSO 72 mg/mL
Ethanol 20 mg/mL
Blood 25-hydroxyvitamin D3 concentrations and incident sporadic colorectal adenoma risk: a pooled case-control study.
Fedirko V, et al. Am J Epidemiol. 2010 Sep 1;172(5):489-500. PMID: 20650953.
Megalin-mediated endocytosis of vitamin D binding protein correlates with 25-hydroxycholecalciferol actions in human mammary cells.
Rowling MJ, et al. J Nutr. 2006 Nov;136(11):2754-9. PMID: 17056796.
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|Vitamin E succinate
Vitamin E succinate is a derivative of Vitamin E, VES can block tumor cell cycle in G1 phase, promote tumor cell differentiation and inhibit tumor Cell DNA synthesis, increase the secretion and activation of transfer growth factor β (TGF-β).
Hydroxocobalamin acetate (Vitamin B12a acetate) is an injectable naturally occurring form of vitamin B12.
Eldecalcitol is an analog of 1,25-dihydroxyvitamin D3 that improves bone mineral density.
Thiamine chloride —the biologically active form of vitamin B1—is vital for all cellular life because it is a co-factor for several essential enzymes.
Folic acid, a B vitamin, plays an important role in cell division and in the synthesis of amino acids and nucleic acids like DNA.
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