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BMY-14802 is a potent and selective sigma-1 (σ1) receptor antagonist with an IC50 value of approximately 100 nM. BMY-14802 shows low affinity at serotonin (5-HT) 1A and adrenergic σ1 receptors and minimal activity at dopamine receptors. BMY-14802 has exhibited antipsychotic activity in rodent models and anti-dyskinetic effects against L-DOPA with preservation of antiparkinsonian efficacy.
| Molecular Weight | 348.39 |
| Formula | C18H22F2N4O |
| CAS Number | 105565-56-8 |
| Solubility (25°C) | DMSO: 5 mg/mL (warmed) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] S A Vanecek, et al. Discriminative stimulus characteristics of BMY 14802 in the pigeon
[4] D P Taylor, et al. A role for sigma binding in the antipsychotic profile of BMY 14802?
[5] G R Gewirtz, et al. BMY 14802, a sigma receptor ligand for the treatment of schizophrenia
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