Free shipping on all orders over $ 500

BIBF0775

Cat. No. M10596
BIBF0775 Structure
Synonym:

BIBF-0775

Size Price Availability
5mg USD 180  USD180 4-7 Days
25mg USD 460  USD460 4-7 Days
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

BIBF0775 is a potent and selective inhibitor of the transforming growth factor β receptor I (TGFβRI, Alk5) with an IC50 of 34 nM. BIBF0775 soaked into the kinase domain of TGFβRI.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 494.63
Formula C31H34N4O2
CAS Number 334951-90-5
Purity >99%
Solubility DMSO 28 mg/mL
Storage -20°C, dry, sealed
References

[1] Gerald J Roth, et al. J Med Chem. Design, synthesis, and evaluation of indolinones as inhibitors of the transforming growth factor β receptor I (TGFβRI)

Related TGF-beta/Smad Products
SB-4

SB-4 is a potent benzoxazole bone morphogenetic protein 4 (BMP4) signaling agonist with a EC50 value of 74 nM.

SJ000291942

SJ000291942 is a bone morphogenic protein (BMP) signaling activator.

SM16

SM16 inhibits TGFβ-induced plasminogen activator inhibitor-luciferase activity (IC50=64 nM).

SRI-011381

SRI-011381 is an agonist of the TGF-beta signaling pathway for treatment of Alzheimer's disease.

ITD-1

ITD-1 is a selective inhibitor of TGF-β signaling (IC50 ~ 0.4-0.8 μM).

  Catalog
Abmole Inhibitor Catalog




Keywords: BIBF0775, BIBF-0775 supplier, TGF-beta/Smad, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.