Free shipping on all orders over $ 500


Cat. No. M2597
Betrixaban Structure


Size Price Availability Quantity
10mM*1mL USD 130  USD130 In stock
5mg USD 110  USD110 In stock
10mg USD 175  USD175 In stock
50mg USD 600  USD600 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Betrixaban is a highly potent, selective, and orally efficacious factor Xa inhibitor with IC50 of 1.2 nM(inhibition of Factor 10a).Betrixaban is an oral direct inhibitor being developed for the prevention of venous thromboembolism (VTE).Betrixaban demonstrates antithrombotic activity and appeared well tolerated in knee replacement patients at the doses studied.

Customer Product Validations & Biological Datas
Source Expert Opin Pharmacother (2013). Figure 2. Betrixaban
Method PK--PD analysis
Cell Lines
Concentrations 27.7 ng/mL and 58.6 ng/mL
Incubation Time 3.17 h
Results The median time of maximum plasma concentration (Tmax) for betrixaban occurred at 3.17 h after dosing for both dose groups
Source Expert Opin Pharmacother (2013). Figure 1. Betrixaban
Method PK--PD analysis
Cell Lines
Concentrations 27.7 ng/mL and 58.6 ng/mL
Incubation Time 3.17 h
Results The PK--PD modeling results demonstrated that betrixaban had no effect on cardiac repolarization
Cell Experiment
Cell lines whole blood
Preparation method In a tissue factor-induced thrombin generation assay, betrixaban in concentrations ranging from 5 ng/mL to 25 ng/mL inhibited thrombin generation to a comparable degree as trough, and the peak levels were achieved by 2.5 mg fondaparinux.
Concentrations 5 ng/mL to 25 ng/mL
Incubation time 3–4 h
Animal Experiment
Animal models rabbit vena cava
Formulation 0.5% methylcellulose
Dosages 3 mg/kg
Administration i.v.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 451.91
Formula C23H22ClN5O3
CAS Number 330942-05-7
Purity >98%
Solubility DMSO 10 mM
Storage at -20°C

[1] Chan NC, et al. Vasc Health Risk Manag. Profile of betrixaban and its potential in the prevention and treatment of venous thromboembolism

[2] Turpie AG,et al. Thromb Haemost. A randomized evaluation of betrixaban, an oral factor Xa inhibitor, for prevention of thromboembolic events after total knee replacement (EXPERT).

Related Factor Xa Products
Ozagrel sodium

Ozagrel(OKY-046) sodium salt is an antiplatelet agent working as a thromboxane A2 synthesis inhibitor.


Ozagrel is a potent and selective thromboxane A2 synthetase inhibitor with an IC50 of 4 nM.

Edoxaban Tosylate Monohydrate

Edoxaban is a selective factor Xa inhibitor with Ki of 0.561 nM, >10 000-fold selectivity over thrombin and FIXa, and is also an orally bioavailable anticoagulant compound.


Rivaroxaban (Xarelto, BAY 59-7939) is oral direct factor Xa inhibitor with an IC50 value of 2.1nM.


Apixaban is a highly selective, reversible and direct factor Xa inhibitor with an IC50 of 0.22±0.02 µM.

Abmole Inhibitor Catalog

Keywords: Betrixaban, PRT-054021 supplier, Factor Xa, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.