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β-Carotene

Cat. No. M4587
β-Carotene Structure
Synonym:

Provitamin A; Carotaben; beta-Carotene; Lucarotin

Size Price Availability Quantity
20mg USD 120  USD120 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Beta-carotene (Provitamin A) is A class of carotenoid compounds that are naturally occurring precursors of vitamin A. Beta-carotene is a ROS regulator with antioxidant and anti-inflammatory activities. β -carotene can be either an antioxidant or a pro-oxidant, depending on its intrinsic properties and the REDOX potential of the biological environment it acts on. β -carotene can induce apoptosis of breast cancer cells and has anti-cancer activity.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 536.87
Formula C40H56
CAS Number 7235-40-7
Purity >98%
Solubility
Storage -20°C , protect from light , dry , sealed
References

[1] Graham W Burton, et al. β-Carotene oxidation products - Function and safety

[2] Torsten Bohn, et al. β-Carotene in the human body: metabolic bioactivation pathways - from digestion to tissue distribution and excretion

[3] Yanyan Wang, et al. Progress in metabolic engineering of β-carotene synthesis

[4] Rie Nishiwaki, et al. Beta-carotene

[5] L Patrick. Beta-carotene: the controversy continues

Related Endogenous Metabolite Products
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Hyodeoxycholic acid

Hyodeoxycholic acid is a secondary bile acid formed by intestinal flora in the small intestine and is an agonist of TGR5 (GPCR19). In CHO cells, the EC50 value is 31.6 µM.

Vasopressin

Vasopressin is a cyclic nine-peptide synthesized in the hypothalamus center. Vasopressin participates in the hypothalamic-pituitary-adrenal axis and regulates pituitary corticotropin secretion by enhancing the stimulating effect of corticotropin-releasing factor. Vasopressin can also act as a neurotransmitter, acting by binding to specific G-protein-coupled receptors.

Xanthine Oxidase

Xanthine oxidase (XOD)

Xanthine

Xanthine is a plant alkaloid found in tea, coffee and cocoa that acts as a mild central nervous system activator. Xanthine is also an intermediate of the purine degradation pathway.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: β-Carotene, Provitamin A; Carotaben; beta-Carotene; Lucarotin supplier, Endogenous Metabolite, inhibitors

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