Beta-carotene (Provitamin A) is A class of carotenoid compounds that are naturally occurring precursors of vitamin A. Beta-carotene is a ROS regulator with antioxidant and anti-inflammatory activities. β -carotene can be either an antioxidant or a pro-oxidant, depending on its intrinsic properties and the REDOX potential of the biological environment it acts on. β -carotene can induce apoptosis of breast cancer cells and has anti-cancer activity.
| Molecular Weight | 536.87 |
| Formula | C40H56 |
| CAS Number | 7235-40-7 |
| Solubility (25°C) | DMSO 30 mg/mL |
| Storage | -20°C, dry, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] Graham W Burton, et al. β-Carotene oxidation products - Function and safety
[3] Yanyan Wang, et al. Progress in metabolic engineering of β-carotene synthesis
| Related Metabolite/Endogenous Metabolite Products |
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| Allolithocholic acid
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