Beta-carotene (Provitamin A) is A class of carotenoid compounds that are naturally occurring precursors of vitamin A. Beta-carotene is a ROS regulator with antioxidant and anti-inflammatory activities. β -carotene can be either an antioxidant or a pro-oxidant, depending on its intrinsic properties and the REDOX potential of the biological environment it acts on. β -carotene can induce apoptosis of breast cancer cells and has anti-cancer activity.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
|Storage||-20°C , protect from light , dry , sealed|
|Related Endogenous Metabolite Products|
Coenzyme A is an essential cofactor in all living cells synthesized by Vitamin B5, ATP, and cysteine.
Hyodeoxycholic acid is a secondary bile acid formed by intestinal flora in the small intestine and is an agonist of TGR5 (GPCR19). In CHO cells, the EC50 value is 31.6 µM.
Vasopressin is a cyclic nine-peptide synthesized in the hypothalamus center. Vasopressin participates in the hypothalamic-pituitary-adrenal axis and regulates pituitary corticotropin secretion by enhancing the stimulating effect of corticotropin-releasing factor. Vasopressin can also act as a neurotransmitter, acting by binding to specific G-protein-coupled receptors.
Xanthine oxidase (XOD)
Xanthine is a plant alkaloid found in tea, coffee and cocoa that acts as a mild central nervous system activator. Xanthine is also an intermediate of the purine degradation pathway.
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