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Bestatin hydrochloride

Cat. No. M14298
Bestatin hydrochloride Structure
Synonym:

Ubenimex hydrochloride

Size Price Availability Quantity
10mg USD 87  USD87 In stock
50mg USD 215  USD215 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Bestatin hydrochloride is an inhibitor of CD13 (Aminopeptidase N)/APN and leukotriene A4 hydrolase, used for cancer research.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 344.83
Formula
CAS Number 65391-42-6
Purity >99%
Solubility DMSO 150 mg/mL
Water 90 mg/mL
Storage 2-8°C, sealed
References

[1] Huina Wu, et al. A new method to evaluate the enzyme-suppressing activity of a leucine aminopeptidase 3 inhibitor

[2] Huijie Liu, et al. New Method for Detecting the Suppressing Effect of Enzyme Activity by Aminopeptidase N Inhibitor

[3] Xiaokui Huo, et al. Enhancement effect of P-gp inhibitors on the intestinal absorption and antiproliferative activity of bestatin

[4] Mohana Krishnamoorthy, et al. Exploration of Sitagliptin as a potential inhibitor for the M1 Alanine aminopeptidase enzyme in Plasmodium falciparum using computational docking

[5] Iwona Kudyba, et al. Asymmetric nitroaldol reaction. Synthesis of taxotere side chain and (-)-bestatin using (1R)-8-phenylmenthyl glyoxylate

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Keywords: Bestatin hydrochloride, Ubenimex hydrochloride supplier, Aminopeptidase, inhibitors

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