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BAY-747

Cat. No. M25613
BAY-747 Structure
Size Price Availability Quantity
10mg USD 150  USD150 In stock
25mg USD 250  USD250 In stock
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Quality Control & Documentation
Biological Activity

Chemical Information
Molecular Weight 440.82
Formula C17H16ClF3O6S
CAS Number 335104-84-2
Form Solid
Storage RT
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Frank Wunder, et al. Br J Pharmacol. Identification and characterization of the new generation soluble guanylate cyclase stimulator BAY-747 designed for the treatment of resistant hypertension

[2] Alexandros Vakalopoulos, et al. J Med Chem. New Generation of sGC Stimulators: Discovery of Imidazo[1,2- a]pyridine Carboxamide BAY 1165747 (BAY-747), a Long-Acting Soluble Guanylate Cyclase Stimulator for the Treatment of Resistant Hypertension

[3] Ellis Nelissen, et al. Sci Rep. The sGC stimulator BAY-747 and activator runcaciguat can enhance memory in vivo via differential hippocampal plasticity mechanisms

[4] Shalini Murali Krishnan, et al. Int J Mol Sci. Assessing the Use of the sGC Stimulator BAY-747, as a Potential Treatment for Duchenne Muscular Dystrophy

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