AZP-531 is an analogue of unacylated ghrelin designed to improve glycaemic control and reduce weight.
Molecular Weight | 962.02 |
CAS Number | 1088543-62-7 |
Form | Solid |
Solubility (25°C) | Water 90 mg/mL |
Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[5] Soraya Allas, et al. Clinical perspectives for ghrelin-derived therapeutic products
Related Ghrelin Receptor/GHSR Products |
---|
des-Gln14-Ghrelin
des-Gln14-Ghrelin is a second endogenous ligand for the growth hormone secretagogue receptor. |
Obestatin(rat)
Obestatin(rat), encoded by the Ghrelin gene, is a cpeptide, comprised of 23 amino acids. |
Human growth hormone-releasing factor
Human growth hormone-releasing factor (Growth Hormone Releasing Factor human) is a hypothalamic polypeptide and stimulates GH production and release by binding to the GHRH Receptor (GHRHR) on cells in the anterior pituitary. |
[His1, Nle27] GHRF (1-32), amide, human
[His1,Nle27] GHRF (1-32), amide, human is a Growth hormone releasing hormone (GHRH) analog. |
Obestatin(rat) TFA
Obestatin(rat) TFA, encoded by the Ghrelin gene, is a cpeptide, comprised of 23 amino acids. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.