Avotaciclib hydrochloride is the hydrochloride form of Avotaciclib, a CDK1 inhibitor.
| Molecular Weight | 317.73 |
| Formula | C13H12ClN7O |
| Form | Solid |
| Storage | 4°C, protect from light, dry, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[3] Chuangchuang Xu et al. Org Biomol Chem. Metal-free and regiospecific synthesis of 3-arylindoles
[4] S Groszkowski et al. Pol J Pharmacol Pharm. 1-Haloacylpiperazines
| Related CDK Products |
|---|
| PF-07224826
PF-07224826 is a CDK2/4/6 inhibitor. |
| INCB123667
INCB123667 is a CDK2 inhibitor. |
| Senexin B
Senexin B is a potent, orally active CDK8/19 inhibitor with Kd values of 140 nM and 80 nM for CDK8 and CDK19, respectively. |
| Q901
Q901 is a CDK7 inhibitor for tumor-related studies. |
| NUV-422
NUV-422 is a CDK2/4/6 inhibitor that can be used in studies related to malignant gliomas. |
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