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Arg34GLP-1(7-34) (human) 

Cat. No. M29131
Arg34GLP-1(7-34) (human)  Structure
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Biological Activity

Arg34GLP-1(7-34) (human) is a polypeptide.

Chemical Information
Molecular Weight 3383.69
Formula C151H228N42O47
CAS Number 204521-68-6
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Food Safety Commission of Japan. Food Saf (Tokyo). Mepanipyrim (Pesticides)

[2] Ru Wang, et al. BMC Cancer. The Clinicopathological features and survival outcomes of patients with different metastatic sites in stage IV breast cancer

[3] Julie W Rutten, et al. Genet Med. The effect of NOTCH3 pathogenic variant position on CADASIL disease severity: NOTCH3 EGFr 1-6 pathogenic variant are associated with a more severe phenotype and lower survival compared with EGFr 7-34 pathogenic variant

[4] Brittany N Bohinc, et al. Prog Mol Biol Transl Sci. Arrestins in bone

[5] Ely M Sebastian, et al. Bone. Differential effects of intermittent PTH(1-34) and PTH(7-34) on bone microarchitecture and aortic calcification in experimental renal failure

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