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Angiotensin II human

Cat. No. M6240
Angiotensin II human Structure
Synonym:

Angiotensin II; Hypertensin II; Ang II; DRVYIHPF

Size Price Availability Quantity
10mg USD 83 In stock
50mg USD 310 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

In vitro: Most of the known actions of Angiotensin II (Ang II) are mediated by AT1 receptors, the AT2 receptor contributes to the regulation of blood pressure and renal function. Angiotensin II raises blood pressure (BP) by a number of actions, the most important ones being vasoconstriction, sympathetic nervous stimulation, increased aldosterone biosynthesis and renal actions. Other Angiotensin II actions include induction of growth, cell migration, and mitosis of vascular smooth muscle cells, increased synthesis of collagen type I and III in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. These actions are mediated by type 1 Ang II receptors (AT1). At the cellular level, responsiveness to Angiotensin II is conferred by the expression of the two classes of angiotensin receptors (AT1 and AT2). The effects of Angiotensin II to increase blood pressure are mediated by AT1 receptors.

In vivo: To distinguish the AT1 receptor population that is critical for the pathogenesis of hypertension, osmotic minipumps are implanted s.c. into each animal to infuse Angiotensin II (1,000 ng/kg/min) continuously for 4 weeks. Angiotensin II causes hypertension by activating AT1 receptors in the kidney promoting sodium reabsorption.

Protocol
Cell Experiment
Cell lines
Preparation method
Concentrations
Incubation time
Animal Experiment
Animal models (129×C57BL/6) F1 mice lacking AT1A receptors for Angiotensin II
Formulation -
Dosages 1,000 ng/kg/min
Administration implanted s.c.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 1046.18
Formula C50H71N13O12
CAS Number 4474-91-3
Purity >98%
Solubility 50 mg/mL in water
Storage at -20°C
References

Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney.
Crowley SD, et al. Proc Natl Acad Sci U S A. 2006 Nov 21;103(47):17985-90. PMID: 17090678.

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Keywords: Angiotensin II human, Angiotensin II; Hypertensin II; Ang II; DRVYIHPF supplier, Angiotensin Receptor, inhibitors

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