Free shipping on all orders over $ 500

Amprenavir

Cat. No. M3578
Amprenavir Structure
Size Price Availability Quantity
5mg USD 80 In stock
50mg USD 560 In stock
Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Amprenavir is an human immunodeficiency virus (HIV) protease inhibitor with IC50 of 14.6 ?12.5 ng/ml for wild-type HIV isolates. Like all HIV protease inhibitors, amprenavir interrupts the maturation phase of the HIV replicative cycle by forming an inhibitor-enzyme complex, which prevents HIV protease from binding with its normal substrates. It has an enzyme inhibition constant (Ki = 0.6 nM) that falls within the Ki range of the other protease inhibitors.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 505.63
Formula C25H35N3O6S
CAS Number 161814-49-9
Purity >99%
Solubility DMSO 10 mg/mL
Ethanol 100 mg/mL
Storage at -20°C
Related HIV Protease Products
Darunavir

Darunavir is a nonpeptidic HIV protease inhibitor, used to treat HIV infection.

Saquinavir Mesylate

Saquinavir mesylate is an HIV Protease Inhibitor used in antiretroviral therapy.

Saquinavir

Saquinavir(Ro 31-8959) is an HIV Protease inhibitor used in antiretroviral therapy.

Atazanavir

Atazanavir is an azapeptide and HIV-protease inhibitor that is used in the treatment of HIV infections and AIDS in combination with other anti-HIV agents.

Dolutegravir sodium

Dolutegravir sodium is a potent, second generation HIV integrase inhibitor (IC₅₀ = 2.7 nM) that displays potent antiviral activity.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Amprenavir supplier, HIV Protease, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.