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Alogliptin Benzoate

Cat. No. M5399
Alogliptin Benzoate Structure
Synonym:

SYR-322

Size Price Availability Quantity
10mg USD 65  USD65 In stock
50mg USD 215  USD215 In stock
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Quality Control & Documentation
Biological Activity

Alogliptin is a potent, selective inhibitor of DPP-4 with IC50 of <10 nM, exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9.

Chemical Information
Molecular Weight 461.51
Formula C18H21N5O2.C7H6O2
CAS Number 850649-62-6
Solubility (25°C) 68 mg/mL in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Saisho Y, et al. Vasc Health Risk Manag. Alogliptin benzoate for management of type 2 diabetes.

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  Catalog
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Keywords: Alogliptin Benzoate, SYR-322 supplier, Dipeptidyl Peptidase, inhibitors, activators


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