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Ademetionine

Cat. No. M5388
Ademetionine Structure
Synonym:

S-Adenosyl-L-methionine; S-Adenosyl methionine; SAMe; AdoMet

Size Price Availability Quantity
50mg USD 90  USD90 In stock
100mg USD 155  USD155 In stock
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Quality Control & Documentation
Biological Activity

Ademetionine(S-adenosyl-l-methionine; SAMe) is a naturally-occurring substance which is a major source of methyl groups in the brain.

Chemical Information
Molecular Weight 398.44
Formula C15H22N6O5S
CAS Number 29908-03-0
Solubility (25°C) Water ≥ 40 mg/mL
DMSO 80 mg/mL
Storage 4°C, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Guangchao Zhao, et al. Ann Clin Transl Neurol . Hyperhomocysteinemia is key for increased susceptibility to PND in aged mice

[2] Hanae Izu, et al. Biosci Biotechnol Biochem . Anti-diabetic effect of S-adenosylmethionine and α-glycerophosphocholine in KK-A y mice

[3] Singh T, et al. J Indian Med Assoc. Heptral (ademetionine) in patients with intrahepatic cholestasis in chronic liver disease due to non-alcoholic liver disease: results of a multicentre observational study in India.

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Keywords: Ademetionine, S-Adenosyl-L-methionine; S-Adenosyl methionine; SAMe; AdoMet supplier, Metabolite/Endogenous Metabolite, inhibitors, activators


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