AcLys-PABC-VC-Aur0101 intermediate-1 is a cathepsin cleavable ADC linker that is used for making antibody-drug conjugate.
| Molecular Weight | 771.9 |
| Formula | C41H53N7O8 |
| CAS Number | 1609108-48-6 |
| Solubility (25°C) | DMSO 100 mg/mL (Need ultrasonic) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] Lucas Quiquempoix et al. J Org Chem. Synthesis of 2,3,4-Trideoxy-2,3,4-trifluoroglucose
[2] Guido Finazzi et al. Blood Cancer J. Prefibrotic myelofibrosis: treatment algorithm 2018
| Related ADC Linker Products |
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| DBCO-acid
DBCO-acid is a cleavable ADC linker used in the synthesis of ADC linker DBCO-NHS ester, and agent-linker conjugates DBCO-PEG-MMAE. |
| Boc-Gly-Gly-Phe-Gly-OH TFA
Boc-Gly-Gly-Phe-Gly-OH TFA, a self-assembly of N- and C-protected tetrapeptide, is a protease cleavable linker used for the antibody-drug conjugate (ADC). |
| Boc-Gly-Gly-Phe-Gly-OH
Boc-Gly-Gly-Phe-Gly-OH, a self-assembly of N- and C-protected tetrapeptide, is a protease cleavable linker used for the antibody-drug conjugate (ADC). |
| Fomc-Gly-Gly-Phe-Gly-OH
Fomc-Gly-Gly-Phe-Gly-OH can be used as an intermediate in the synthesis of ADC dual-drug-linker. |
| Mc-Gly-Gly-Phe-Gly-PAB-OH
Mc-Gly-Gly-Phe-Gly-PAB-OH (Mc-GGFG-PAB-OH) is a cleavable ADC linker used for antibody-drug conjugates (ADCs). |
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